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LAS VEGAS (AP) - Authorities in the Philippines have arrived in search of a rare rare drug known asLivalo.(LASVIGAN)

The official website of the National Drug Authority (NDA), which regulates the drug distribution and supply chain in the country, said the suspected Livalo was manufactured in the Philippines by Sun Pharma. "It is a potent and highly effective treatment for male sexual dysfunction," it said in a statement.

Livalo, whose active ingredient is tadalafil, is an erectile dysfunction drug used to treat a variety of conditions. It is used to treat a condition known as benign prostatic hyperplasia or BPH, in which the prostate gland enlarges, and erectile dysfunction.

Sun Pharma, the main manufacturer in the Philippines, said it was producing Livalo for distribution to doctors in the country in the hopes of improving treatment.

The drug is available in the United States under the brand name Cialis and in Europe by a different name called Levitra.

"Livalo is a highly effective and well-tolerated treatment for erectile dysfunction, and is available in the United States and elsewhere," it said in the statement.

The official website of the drug authority said it had received orders from the pharmaceutical company for production of Livalo in the Philippines.

Livalo is the active ingredient in vardenafil, the brand name of Levitra.

The official website also said it was supplying the product to the public through the Internet.

"Livalo has a high potential for abuse and misuse," it said in the statement.

The official website also said the product was being offered in different strengths depending on the country.

The drugmaker said it was not aware of any reports of misuse on the official website.

Livalo is known as "Levitra", or "Vardenafil".

Livalo is the most common treatment for male sexual dysfunction in men.

It is used to treat the symptoms of BPH, in which the prostate gland enlarges, and erectile dysfunction, which is caused by insufficient blood flow to the penis, the official website said.

The drug is effective only after sexual stimulation.

The official website said the drug had side effects such as headache, nausea, and dizziness.

It said it was not aware of any reports of misuse of the drug.

Livalo is sold in tablet form and is taken orally.

The official website of the drug authority said the drugmaker had received orders for the production of Livalo in the Philippines. It said it had received orders from the pharmaceutical company for the production of Livalo in the Philippines.

The official website said the drug had been available in the United States for three months.

Livalo is available for sale at a price of $2.90, but not in the US.

AP Business Writer Rakesh Kaul is a freelance writer based in New York City and covers business, politics, health, and technology. Follow him on Twitter at @RakeshKaulAP Business Writer Rakesh Kaul is a freelance writer based in New York City and covers business, politics, health, and technology. Follow him on Twitter at

Livalo (Cialis)

Livalo was manufactured by Sun Pharma and is available in the Philippines as a tablet. However, the official website says that the product was not available in the US.

Sun Pharma, which makes the drug, said in a statement: "Sun Pharma is the leading manufacturer of vardenafil in the Philippines. The official website of the drug authority explains that the manufacturer, Sun Pharma, has been working on a drug that works for men with erectile dysfunction. We are very pleased to be able to supply vardenafil to the public and we are confident that we can supply vardenafil to the public in the US."

It said that the product was manufactured in India and it was distributed in the Philippines through various distribution channels. It said that the official website said that the product was manufactured in the Philippines by Sun Pharma.

Livalo is the active ingredient in the drug, tadalafil.

Livalo is known as "Vardenafil".

It was reported in the medical journal "Premature Ejaculation" last year that the drug had been on the market since 2007.

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

If you are taking Cialis or related medications, it is important for your doctor to determine whether Cialis is the right treatment for you. Specifically, they may consider the following:

  1. The appropriate dosage for best results
  2. Whether Cialis is the treatment of choice in individuals with type 2 diabetes or pulmonary arterial hypertension
  3. Side effects (e.g., nausea, dizziness, fatigue) that can be potentially dangerous
  4. The potential risk of priapism

C.

Both Cialis and alpha-blockers can interact with grapefruit and grapefruit juice, increasing the risk of side effects. Here are the key drug-food Interactions:

  1. Grapefruit: Grapefruits are high in caffeine and cactin, causing symptoms like dizziness, lightheadedness, or fainting. It is recommended that you avoid consuming grapefruit or grapefruit juice while taking Cialis.

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